Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

Nucleoid-associated proteins in Crenarchaea.

Architectural proteins play an important role in compacting and organizing the chromosomal DNA in all three kingdoms of life (Eukarya, Bacteria and Archaea). These proteins are generally not conserved at the amino acid sequence level, but the mechanisms by which they modulate the genome do seem to be functionally conserved across kingdoms. On a generic level, architectural proteins can be class...

Multimedia software to help caregivers cope.

OBJECTIVE This report describes the design and evaluation of a software application to help carers cope when faced with caring problems and emergencies. DESIGN The design process involved users at each stage to ensure the content of the software application was appropriate, and the research team carefully considered the requirements of disabled and elderly users. MEASUREMENTS Focus group di...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.

The mutagenicity of DNA double-strand break repair in Escherichia coli is controlled by DNA-damage (SOS) and general (RpoS) stress responses, which let error-prone DNA polymerases participate, potentially accelerating evolution during stress. Either base substitutions and indels or genome rearrangements result. Here we discovered that most small basic proteins that compact the genome, nucleoid-...

Can the Internet cope with stress?

When will the Internet wake up and become aware of itself? In this note the problem is approached by asking an alternative question: Can the Internet cope with stress? By extrapolating the psychological difference between coping and defense mechanisms a distributed software experiment is outlined which could reject the hypothesis that the Internet is not a